A pill to end drug injections

It can inject medicines like insulin from inside the stomach
Here was the challenge for bioengineers: find a way for patients to take drugs — like insulin or monoclonal antibodies used to treat cancers and other diseases — without injections. The medicines are made of molecules too big to be absorbed through the stomach or intestines; in any event, the drugs would be quickly degraded by the body’s harsh digestive system. Now, a team of scientists may have found a solution that delivers these drugs in a capsule a person can swallow. The test device, called Soma, is shaped like the tortoise’s shell. Inside is a miniature post made of insulin. After the tiny device positions itself against the stomach wall, the post pops out and injects insulin. The device then travels through the colon and eventually is eliminated by the patient. The device works in rats and pigs, the investigators reported on Thursday in the journal Science . The researchers — at the Massachusetts Institute of Technology, Harvard and Novo Nordisk, the pharmaceutical company — hope to start testing Soma in humans in three years.
Outside experts said the device may well be a viable solution to the injection problem.
“It’s a very new concept and a really cool idea,” said Edith Mathiowitz, a professor of medical science and engineering at Brown University. “What they have done is taken ideas from many areas and integrated them,” said Tejal Desai, chair of bioengineering and therapeutic sciences at the University of California, San Francisco. The researchers knew that if they could get a drug through the wall of the stomach, the medicine would enter the bloodstream. Because the stomach does not have many pain receptors, a prick from the tiny post would not even be felt. Creating a device to accomplish this required three key advances, said Dr. Giovanni Traverso, a gastroenterologist and a lead author of the paper. The first challenge was to make a device that would land on the stomach in a predictable way. For ideas, the researchers looked to nature — and discovered the leopard tortoise. An angled shell helps the tortoise roll back onto its feet no matter which way it falls. The engineers decided to imitate the tortoise’s shape with a tiny device that would always land on the wall of the stomach. Next, they needed a cue that would trigger the release of a tiny post made of insulin that they would put in the device. Finally, they had to make that tiny insulin post. The device that would hold it is small, which restricted how much drug it could contain.NY Times

Source : https://www.thehindu.com/todays-paper/tp-life/a-pill-to-end-drug-injections/article26220458.ece

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