DATABASE OF GENOMIC VARIANTS OF ORAL CANCER

Recently, the National Institute of Biomedical Genomics (NIBMG), funded by the Department of Biotechnology, has created the world’s first database of genomic variations in oral cancer (dbGENVOC).

Important points:

  • dbGENVOC, a comprehensive, flexible database framework, developed with an aim to allow potential users to access, query, browse and download clinically relevant somatic and germline variation data from Indian oral cancer patients.
  • Somatic or acquired genomic variants are the most common cause of cancer, occurring from damage to genes in an individual cell during a person’s life.
  • A germline variant occurs in gametes and is passed directly from a parent to a child at the time of conception. Cancers caused by germline pathogenic variants are called inherited or hereditary.
  • It will be updated annually with variation data from new oral cancer patients from different regions of India and southeast Asia.
  • According to the World Cancer Report 2020, India had an estimated 1.16 million new cancer cases in 2018.
  • 1 in 10 Indians will develop cancer during their lifetime and 1 in 15 will die of the disease.
  • The six most common cancer types in India are breast cancer, oral cancer, cervical cancer, lung cancer, stomach cancer, and colorectal cancer.
  • Oral cancer is the most prevalent form of cancer among men in India, largely fuelled by tobacco-chewing.

SOURCE: THE HINDU,THE ECONOMIC TIMES,MINT

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