• Newly synthesised biocompatible drug delivery system combined with anti-inflammatory drugs brings potential solution for rheumatoid arthritis
  • Scientists explored the potential of the anti-inflammatory FDA-approved drug 9-aminoacridine (9AA) and the natural compound caffeic acid (CA), generally found in coffee or wine conjugated to nano micelles, an amphiphilic molecule that forms spherical structure when immersed in water, for the treatment of RA.
  • It can help ameliorate the pain associated with the disease as well as cure the disease by restoring cartilage integrity which provides the flexibility to the bone.
  • Inflammation plays an important role in the development of rheumatoid arthritis (RA).
  • As a result, strategies for treating RA have been largely focused on providing symptomatic relief from pain and permanent cure is not available.
  • Methotrexate (MTX) is considered as golden standard for the therapy of the disease but due to its severe side effects, researchers are currently looking for alternate drugs or strategies to overcome the disease.

What is rheumatoid arthritis (RA)?

  • Rheumatoid arthritis, or RA, is an autoimmune and inflammatory disease, which means that your immune system attacks healthy cells in your body by mistake, causing inflammation (painful swelling) in the affected parts of the body.
  • RA mainly attacks the joints, usually many joints at once.
  • The tissue damage can cause long-lasting or chronic pain, unsteadiness (lack of balance), and deformity (misshapenness).


  • RA is the result of an immune response in which the body’s immune system attacks its own healthy cells.
  • The specific causes of RA are unknown.


  • Treatment for RA usually includes the use of medications that slow disease and prevent joint deformity, called disease-modifying antirheumatic drugs (DMARDs).
  • Biological response modifiers (biologicals) are medications that are an effective second-line treatment.
  • In addition to medications, people can manage their RA with self-management strategies proven to reduce pain and disability.


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